Production yields at the distal fall-off of the β+ emitters 11C and 13N for in-vivo range verification in proton therapy

In proton therapy, Positron Emission Tomography (PET) range verification relies on the comparison of measured and estimated activity distributions from β + emitters produced by beam in patient. The accuracy is basically that underlying reaction cross section data. this context, we have developed a new method for measuring production yields combining multi-foil technique with clinical PET scanner, resulting energy differential sections single irradiation. has been applied to C 11 (t 1/2 = 20.36 min) N y 13 9.97 min), main candidates off-line verification, carbon, nitrogen oxygen, elements human body. studied 18 MeV CNA cyclotron corresponds distal fall-off curve, i.e. near Bragg peak. • Development measure yield β+ induced charged particles. Combination activation detection annihilation radiation scanner. Reaction up MeV: 14 N(p,α) C, 12 C(p,γ) N, 16 O(p,α) O(p,3p3n) C.